Discover better hits and drive leads faster to in vivo, IND, and clinical trials.
Time to market is critical. Our 3D Immuno-Oncology (IO) Platform and 3D cell model expertise will shorten assay development timelines and lead to faster results.
Offered through collaboration, our 3D IO Platform utilizes our patented cell patterning technology to recreate the 3D tumor microenvironment physiology of tumor, stroma and immune.
We personalize the platform to your particular immunotherapy program for your in-house screening and translational studies.
Immune Infiltration and Tumor Killing
A successful immunotherapy requires immune infiltration in order for immune cells to reach and attack cancer cells. Our 3D IO Platform reconstitutes the extracellular matrix (ECM) microenvironment and ensures physiologically relevant immune-tumor interactions in your immunotherapy efficacy evaluation.
With Stromal Fibroblasts
Stromal engagement and barrier function often complicate immune activation and infiltration. The incorporation of dense fibroblasts around the tumor recapitulates the desmoplastic stroma in some cancers and is essential for correctly assaying immunotherapy efficacy in the context of the tumor microenvironment.
With Endothelial Barrier
A functional vasculature is a prerequisite for immune cell recruitment and distribution in the tumor tissue. Aberrant vasculature in the tumor often impairs immune penetration in immunotherapy. The endothelial barrier assay can recapitulate immune infiltration of the tumor vascular endothelium layer.